NAD+
Nicotinamide Adenine Dinucleotide
Dosage
500mg / 1000mg
Unit Size
1 Vial
// Add to Cart
500mg
$140.00
33 in stock
1000mg
$240.00
99 in stock
What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell and is essential for over 500 enzymatic reactions. It is the critical molecule linking cellular metabolism to energy production, DNA repair, and longevity signaling. NAD+ levels decline by approximately 50% between age 40 and 60, making its restoration one of the most active areas in aging and metabolic research.
500+
Enzymatic Reactions
~50%
Decline by Age 60
Every Cell
Production Site
Key Benefits
Cellular Energy (ATP)
Serves as the primary electron carrier in mitochondrial ATP synthesis — fueling every cell in the body.
Sirtuin Activation
Required substrate for sirtuins (SIRT1-7), the longevity proteins that regulate gene expression and metabolic health.
DNA Repair
Activates PARP enzymes responsible for detecting and repairing DNA strand breaks, protecting genomic integrity.
Neuroprotection
Studied for neuroprotective effects through support of neuronal energy metabolism and reduction of oxidative stress.
Muscle Function
Preclinical studies show NAD+ restoration improves muscle function, endurance, and recovery from exercise-induced damage.
Anti-Aging
Restoring declining NAD+ levels has been associated with improved metabolic health, cognitive function, and longevity markers in research.
How It Works
Electron Transport Chain
NAD+ accepts electrons from metabolic reactions in the citric acid cycle, shuttling them to the mitochondrial electron transport chain to generate ATP.
Sirtuin Substrate
SIRT1-7 deacetylase enzymes consume NAD+ to regulate gene expression, mitochondrial biogenesis, and inflammation — processes central to aging biology.
PARP Activation
PARP-1 and related enzymes use NAD+ as a substrate to detect DNA damage and recruit repair machinery, maintaining genomic stability.
Circadian & Metabolic Regulation
NAD+ oscillates with circadian rhythms, connecting the body's internal clock to metabolic gene expression and energy balance.
Common Protocol (Research Reference)
500 mg
Dose per session
2–3×/week
Frequency
8–12 wks
Typical cycle length
Research Use Notice
NAD+ is a research peptide not approved by the FDA for human use. This information is for educational purposes only. Always consult a qualified healthcare professional before considering any peptide protocol.