MOTS-c
Mitochondrial Derived Peptide
Dosage
10mg
Unit Size
1 Vial
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10mg
$80.00
19 in stock
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide encoded within the 12S ribosomal RNA gene of mitochondrial DNA — making it one of very few peptides produced directly by mitochondria rather than nuclear DNA. It functions as a metabolic regulator that travels to muscle tissue and the nucleus to influence energy metabolism, insulin sensitivity, and cellular stress responses.
16 aa
Amino Acid Chain
Mitochondrial
Gene Origin
AMPK
Primary Pathway
Key Benefits
Mitochondrial ATP Production
Enhances mitochondrial efficiency and ATP synthesis, boosting cellular energy output.
Insulin Sensitivity
Improves glucose uptake and insulin signaling in skeletal muscle — reducing metabolic dysregulation.
Stress Resistance
Activates cellular stress response pathways, improving resilience to oxidative and metabolic stress.
Muscle Growth Support
Studied for its role in promoting muscle mass maintenance and metabolic efficiency in aging models.
Anti-Aging Metabolism
MOTS-c levels decline with age; research suggests restoration may reverse age-related metabolic decline.
Aerobic Capacity
Supports aerobic metabolism and oxygen utilization, improving endurance capacity in preclinical studies.
How It Works
AMPK Pathway Activation
MOTS-c activates AMP-activated protein kinase (AMPK), the master regulator of cellular energy homeostasis, improving metabolic efficiency.
Nuclear Gene Regulation
Unlike most mitochondrial peptides, MOTS-c translocates to the cell nucleus where it directly regulates the expression of nuclear genes involved in metabolism.
GLUT4 Translocation
Promotes GLUT4 glucose transporter translocation to the cell surface, enhancing insulin-independent glucose uptake in muscle tissue.
Mitochondrial Stress Response
Activates the mitochondrial unfolded protein response (UPRmt), a longevity-associated pathway that improves mitochondrial quality control.
Common Protocol (Research Reference)
10–15 mg
Dose per injection
1–2×/week
Frequency
4–8 wks
Typical cycle length
Research Use Notice
MOTS-c is a research peptide not approved by the FDA for human use. This information is for educational purposes only. Always consult a qualified healthcare professional before considering any peptide protocol.